In the mid-1800s, the United States underwent a tremendous migration West spawned by the news of unlimited land. The Overland Trail was one of the most highly used Western routes. The Trail led pioneers straight through the Wyoming High Plains, which included the Laramie Valley. It has been recorded that between 1862 and 1868 over a hundred thousand people traversed through the rugged Western terrain by way of the Overland Trail.

Harmony Elementary School was officially established in 1922 near what is now Harmony Lane, 20 miles southwest of Laramie. It started out as a log cabin and was also the central meeting place for social gatherings in the Harmony area. During that time, the schoolmarm was transported to and from school by horse and wagon. During the long winter months, the wagon was transformed into a sleigh. In 1952, a brick schoolhouse and basement were built. At that time, the school was divided into two sections referred to by the children as a room for the “little kids” and one for the “big kids.” Other smaller rural schools were absorbed into the “Harmony District” and it remains one of the oldest operating rural schools in the area. Harmony School was District 10 until it joined Albany County School District 1, in 1971. The Harmony School was once located on a plot of land next to the old Harmony Church. Rancher, Mr. Lewis, donated a parcel of land to the school district with the stipulation that the school would always remain open, and it would serve as the local community center. A gymnasium was added to the school in 1987. Five years later classrooms were added down the length of the building. At one time, students from kindergarten to eighth grade were in attendance.  Today, Harmony has three classrooms serving students in kindergarten through fifth grade.